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Ireland have won the last four Tests against England but only one of those matches was at Twickenham.
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Ireland: 15 Hugo Keenan, 14 Calvin Nash, 13 Robbie Henshaw, 12 Bundee Aki, 11 James Lowe, 10 Jack Crowley, 9 Jamison Gibson-Park, 8 Caelan Doris, 7 Josh van der Flier, 6 Peter O’Mahony (c), 5 Tadhg Beirne, 4 Joe McCarthy, 3 Tadhg Furlong, 2 Dan Sheehan, 1 Andrew Porter
Replacements: 16 Ronan Kelleher, 17 Cian Healy, 18 Finlay Bealham, 19 Iain Henderson, 20 Ryan Baird, 21 Jack Conan, 22 Conor Murray, 23 Ciaran Frawley
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England: 15 George Furbank, 14 Immanuel Feyi-Waboso, 13 Henry Slade, 12 Ollie Lawrence, 11 Tommy Freeman, 10 George Ford, 9 Alex Mitchell, 8 Ben Earl, 7 Sam Underhill, 6 Ollie Chessum, 5 George Martin, 4 Maro Itoje, 3 Dan Cole, 2 Jamie George (c), 1 Ellis Genge
Replacements: 16 Theo Dan, 17 Joe Marler, 18 Will Stuart, 19 Chandler Cunningham-South, 20 Alex Dombrandt, 21 Danny Care, 22 Marcus Smith, 23 Elliot Daly
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Greetings and a warm welcome to our coverage of the Six Nations match between England and Ireland from Twickenham.
1'
KICK-OFF: Crowley puts the kick-off deep and England opt for the easy exit and put it out on halfway.
2'
Van der Flier uses the pick and go to flummox the England defence and Ireland get rumbling forward. England are stretched and give away a penalty straight in front.
3'
PENALTY, IRELAND, CROWLEY, 0-3:
Crowley slots a smooth kick at goal and Ireland get a good start.
4'
TRY, ENGLAND, LAWRENCE, 5-3:
Lowe's kick clear for Ireland isn't out and here come England. a Slick backline move sets Lawrence into the corner.
6'
Ford cannot convert the try from out wide.
7'
Ireland pour forward in response but they end up making a basic error and the Twickenham crowd are on their backs now.
9'
England win the scrum time penalty and are winning the early battles well. Slade puts a penalty kick right down into the Ireland 22.
10'
Henshaw makes a big tackle and Van der Flier latches on to stop a threatening looking England assualt. Ireland clear up to halfway but then lose the lineout.
12'
A kick ahead from England doesn't go to hand but they are able to force Ireland into touch inside their 22 and now they can attack again from the lineout.
14'
Keenan slams a clearance away after England knock on in attack. Mitchell had a snipe and looked dangerous but couldn't connect with the offload.
16'
Ford tries a drop goal and misses but England have a penalty. George had found a hole to get England going forward and Ireland scrambling back.
17'
PENALTY, ENGLAND, FORD, 8-3:
Ford makes good with this kick to extend England's lead.
19'
Ireland slow things down with a penalty kick to touch. They need to sort out their lineout to keep on the attack.
20'
PENALTY, IRELAND, CROWLEY, 6-8:
Crowley slots the kick.
20'
Ireland attack and Lawrence comes in from the side to end the Irish attack but Crowley will call for the tee.
21'
England are pumped up as Chessum tackles aki into touch close to the Ireland 22 but the England flanker stays down injured.
22'
Ford tries a drop goal which is charged down but England have the ball back and they swarm onto the Irish 22.
23'
England turn down a shot at goal and go to the corner and could set a maul here.
24'
England try a worked move but are stopped short. Ireland snatch it on the line but the clearance doesn't find touch and England come back at them.
25'
Lawrence is over but the ball has been knocked on in the build-up and Ireland survive.
26'
Ireland clear their lines and then muscle the ball back close to halfway but they aren't hitting their straps on attack in this match.
28'
Ireland chase England back into their own 22 with a kick ahead that Gibson-Park might have wanted to stay in-field.
29'
Ireland cough up a lineout penalty and that gives England another easy exit.
31'
England miss a shot at goal and Ireland get away with one thanks to Ford's wayward boot.
34'
Ireland get a chance to retake the lead as Aki gets over the ball and England's enterprise hurts them there.
35'
PENALTY, IRELAND, CROWLEY, 8-9:
Crowley gives Ireland the lead although his kick only just creeps over.
37'
England knock on as they try to go wide to expose the Ireland defence. Ireland will hope for another good exit and to get to half time holding a lead.
38'
Furbank makes a mess of trying to keep Lowe's kick in-field and Ireland suddenly have a lineout on the England 22.
40'
HALF TIME: ENGLAND 8-12 IRELAND:
The penalties at the end of the first half gave Ireland an unlikely lead. England had the impetus for the first half an hour but just lost their way a little bit. Ireland's key players have stepped up when it matters as well.
40'
PENALTY, IRELAND, CROWLEY, 8-12:
Crowley slots the kick and England will be in disbelief.
40'
Ireland have the penalty and will take a shot at goal to end the first half.
41'
England kick deep and Ireland put up a tester but they knock on and England have an attacking scrum early on.
42'
Ireland are in over the ball as England try to breach the Irish 22. Ireland kick the penalty to touch close to halfway.
44'
TRY, IRELAND, LOWE, 8-17:
Lowe dives in at the corner to score for Ireland and that's more like it from them.
45'
Crowley cannot convert but Ireland have a nine-point lead.
46'
Lowe's clearance isn't long after the restart but he finds touch. England go wide after the lineout and find space but lose the ball.
48'
TRY, ENGLAND, FURBANK, 13-17:
England have returned to what was working got them and Furbank sprints in to score as the offload game gets them going forward.
49'
Ford misses the conversion.
50'
Itoje knocks on off the restart and Ireland cannot use the advantage and are brought back to feed a scrum just outside the English 22.
52'
Ireland are overeager at the scrum and England get a free kick to clear their lines.
54'
Ireland get a penalty call for a tight going past the ball incident and kick up towards the England 22.
55'
Ireland hoist but England have the ball close to their line now after the battle in the air goes their way. Ford is rushed and his clearance finds touch inside the England 22.
57'
England get up to steal the lineout but tap in into touch even closer to their line.
58'
YELLOW CARD, IRELAND, O'MAHONY:
O'Mahony has committed a cynical professional foul and can have no complaints with going to the bin. England put the kick out close to the Ireland line.
58'
Ireland knock on as they attack and England have it back and kick.
60'
TRY, ENGLAND, EARL, 18-17:
Earl eventually powers over and England are back in front and a man up.
61'
CONVERSION, ENGLAND, SMITH, 20-17:
Smith converts the try to extend the England lead.
62'
England find a safe touch from a box-kick that takes play within five of the halfway line.
63'
Crowley doesn't have the legs to go for goal but puts his kick into the England 22.
64'
Another knock on in the England 22 could cost Ireland. England kick long but not out and Ireland counter. They knock on again though and England now have a scrum ten inside their own half.
66'
England get it out of the scrum but Smith is hit hard as he kicks and Ireland have it back.
68'
England win the penalty on defence and that is a huge moment for them at home.
69'
Gibson-Park takes the mark and kicks a long touch into the England half.
71'
Ireland win another penalty close to halfway and this match looks set to go down to the wire now. A big kick sets and Ireland lineout ten out.
73'
TRY, IRELAND, LOWE, 20-22:
Ireland work the space ouit wide and Lowe uses that to get over and score in the corner.
74'
Crowley misses the conversion so this remains a two-point game with less than seven minutes to play.
75'
England get a penalty on halfway and Daly has decided to go for it.
76'
Daly pushes his penalty kick just wide and Ireland get a let-off.
78'
England attack but Care kicks it away and Ireland try to clear it but don't find touch.
79'
Murray scrambles a kick into touch close to the ten inside Ireland's half.
79'
Ireland force England into touch just inside their own 22.
80'
DROP GOAL, ENGLAND, SMITH, 23-22:
Smith snaps a drop goal with England playing on an advantage and they snatch a win but it is what they deserve for an outstanding performance.